Tire \Tire\, v. t. To exhaust the strength of, as by toil or labor; to exhaust the patience of; to wear out (one's interest, attention, or the like); to weary; to fatigue; to jade. --Shak. Tired with toil, all hopes of safety past. --Dryden. {To tire out}, to weary or fatigue to exhaustion; to harass. Syn: To jade; weary; exhaust; harass. See {Jade}.